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For instance, macrophage-derived exosomal miR-4532 has been shown to promote endothelial cell injury by targeting SP1 and activating NF-B p65 signaling, leading to increased expression of adhesion molecules such as ICAM-1 and VCAM-1, which facilitate leukocyte adhesion and transmigration [140]

Interactions mediated primarily through the pre-NAC and NAC regions are more likely to inhibit aggregation, whereas interactions restricted to the terminiregions not part of the fibril coremay have little or no influence on Syn aggregation

In contrast to mouse collagen organoids, which predominantly consisted of a single undifferentiated cell population, human collagen organoids exhibited two distinct clusters, annotated as cluster 1 and 2 (Figs