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High doses are primarily necessary in cases of proven deficiency, for example in: - Impaired nutrient absorption in the intestine (e.g., after surgery/in case of stomach problems) - Strict vegan diet with confirmed B12 deficiency - Chronic inflammatory bowel diseases - Elderly people with age-related absorption disorders If you belong to one of these groups, you should consult your doctor to choose the correct dose and method of administration

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Copper toxicity Though its unlikely, copper peptide skin care products may lead to potential copper toxicity if not used as directed by the manufacturer (or if multiple copper-containing products are used together)