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Under hyperglycemic conditions, dysfunction of the mitochondrial electron transport chain (ETC.) leads to excessive ROS production, subsequently inducing oxidative damage, mitochondrial DNA (mtDNA) mutations/leakage, and activation of inflammatory pathways such as the NLR family pyrin domain containing 3 (NLRP3) inflammasome and the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING), thereby exacerbating local and systemic inflammation and hindering wound healing (Deng et al., 2023

Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: a central hub in schizophrenia pathophysiology

Title: Characterization of astrocytes and neurons following pharmacological depletion of microglia in the visual cortex Authors: Sebrena M

The effects of a vitamin injection generally last longer than a standard oral supplement because the nutrients enter circulation immediately and are used more efficiently