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in X-linked protoporphyria (XLP), increased activity is a consequence of gain of function mutations of the first enzyme of the pathway

The genome sometimes accommodates three open studying frames (ORFs): ORF1 encodes a nonstructural polyprotein for virus replication and transcription, ORF2 encodes the capsid protein that elicits neutralizing antibodies, and ORF3, which partially overlaps ORF2 , encodes a multifunctional protein concerned in virion morphogenesis and pathogenesis

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Journal of Clinical Endocrinology & Metabolism, 78(4), 693698