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There are at least five significant roadblocks in transforming preclinical results into clinically applicable antibiotics: absence of reliable animal models, high costs as well as low success rates in clinical trials, lack of economic incentives among producers, poorly chosen areas of research, and gaps in implementation of the best antibiotic stewardship practices [276]

Souza A, S M Dantas D, et al

Then, untargeted metabolomics was applied to plasma and erythrocytes to get a multi-compartmental characterization of the metabolic alterations occurring in the crosstalk between IR and childhood obesity

The interactions of some antioxidant enzymes with oxidants, antioxidants, or other bioactive molecules contribute to the management of NCDs, as briefly described below