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Body weight changes came from metabolic shifts rather than illness or reduced eating

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It should be mentioned that in one study utilizing NA in combination with the NAMPT inhibitor GNE-617, the antitumor activity of the latter was found to be prevented by the concomitant NA administration in NAPRT-deficient tumor xenograft models, which was ascribed to an increased NAM and NAD + production in the liver with the consequent rise in tumor NAM and NAD + levels