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However, the association between the GRK4 variants and hypertension was not found in other studies, which may be age/sex/race/ethnicity-related, or a failure to study all the GRK4 variants [103, 109, 111,112,113,114]

Considering that ROS impacts the activities of epigenetic modulators 129,130,131 , it is reasonable to hypothesize that high levels of ROS generated by increased metabolic rate, gene mutation and relative hypoxia 117 perhaps explain the DNA hypomethylation and GPX7 overexpression seen in gliomas

This may be either because of increased growth potential or the odd number of chromosomes inherent in genetic variations (Ren et al., 2017)

,, Although there are several inhibitors of the cystine/glutamate transporter other than sulfasalazine, these drugs have limitations of low bioavailability and low selectivity to of the cystine/glutamate transporter in vivo