glutathione cisplatin Role of the Metabolic Pathway in Lung Cancer Treatment and Prognosis: A Review File:Cisplatin mechanism.svg - Wikimedia Commons

HO-1 exerts a bidirectional regulatory effect on oxidative stress ( BACH1 and promote the translocation of HO-1 from the cytoplasm to the mitochondria, leading to mitochondrial iron overload and the accumulation of lipid ROS ( Based on current research, the mechanistic interplay between HO-1 and oxidative stress has been partially elucidated

Lu Y, Zhou G, Ewald J, Pang Z, Shiri T, Xia J

Additionally, sulfhydration of Keap1, an E3 ubiquitin ligase substrate adaptor, inhibits its ability to degrade Nrf2, leading to the restoration of antioxidant gene expression

Indeed, QOL is now a routine measurement in all studies assessing the efficacy of therapeutic interventions for diabetic neuropathy and diabetic neuropathic pain