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ZIP14 is also involved in regulating hepatic glucose metabolism with opposite effects compared to adipose tissue

however, a subsequent double-blinded, placebo-controlled trial failed to replicate these benefits and even noted exacerbation in some instances

doi: 10.1016/j.arr.2022.101619

Moreover, patients in the HGSH group showed a higher incidence of postoperative recurrence and metastasis ( P = 0.003) (Table 3), as well as reduced DFS ( P = 0.001) and OS ( P = 0.026) (Fig