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However, it is noteworthy that knockdown of NNMT does not seem to affect NAD + levels in the liver, indicating potential divergent regulatory mechanisms of NNMT in these tissues and suggesting the existence of redundant pathways in NAD + metabolism regulation (Kraus et al., 2014)

Physiologically based pharmacokinetic modeling for sequential metabolism: effect of CYP2C19 genetic polymorphism on clopidogrel and clopidogrel active metabolite pharmacokinetics