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In immunopeptidomics we need a sniper instead of a shotgun

163 As of 2023, 32% of the worlds population lived in regions with mandatory folic acid fortification programs, 53% lived in countries with only voluntary programs, and 15% lived in regions without any folic acid fortification programs

The metabolism and elimination of NAD+ (and its by-products) could be altered in advanced hepatic or renal dysfunction, and high-dose NAD+ might theoretically affect cardiovascular dynamics, so practitioners generally avoid or closely supervise NAD+ use in such settings