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The compromised oral bioavailability and excessive cytotoxic effects of 5AC and decitabine created increased demand for developing new nucleoside analogs such as 6-thioguanine (6-TG), zebularine and guadecitabine (SGI-110)

10.1016/S0887-8994(97)00026-X Warter JM, Imler M, Marescaux C, Chabrier G, Rumbach L, Micheletti G, Krieger J: Sodium valproate-induced hyperammonemia in the rat: role of the kidney