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1 Introduction Hypothyroidism is a prevalent endocrine disorder defined by inadequate synthesis or secretion of thyroid hormones, primarily thyroxine (T 4) and triiodothyronine (T 3) (McDermott, 2020)

The body circadian rhythm consolidates around the restored melatonin production

In conclusion, ROS demonstrate paradoxical effects on EC metabolism and require further study to better understand the complex relationship between redox signaling and EC metabolism and the subsequent functional effects that modulate EC proliferation, migration, and angiogenesis

xido ntrico (NO) perfuso e microcirculao O peptdeo modula a via do xido ntrico, gs de sinalizao que regula vasodilatao