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doi: 10.1186/s12955-019-1165-2 6 BouhanickB.CracowskiJ.FaillieJ.French Society of Pharmacology, Therapeutics (SFPT) (2020)

A review of small-molecule inhibitors of one-carbon enzymes: SHMT2 and MTHFD2 in the spotlight

Cognition-enhancing as well as antidepressant and neuroprotective effects are conferred by 7, 8-Dihydroxyflavone (7, 8-DHF), a high-affinity tropomyosin receptor kinase B (TrkB) agonist that activates downstream signaling ( Table 2 )