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These include a red, swollen tongue, angular cheilitis (sores on the sides of your mouth), and a loss of taste receptors, also known as papillae

The group taking 0.5mg of tesofensine experienced an average weight loss of 13-14kg during this period, which was significantly more than the placebo group

Thus, even though the two mutants are genetically and metabolically very different, in Df1/ + mice, the MMA phenotype was not affected by heterozygosity of other genes in the deletion