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Early studies have demonstrated that staurosporine, a non-selective inhibitor of kinases and well-known inducer of apoptosis, as well as serum deprivation dont trigger cell death in mature erythrocytes [181]

This leads to increase of superoxide radicals and consequently oxidative damage on cones [8]

The mRNA expression levels of IL-1 , CAS-3 , and CAS-9 were analyzed using the LightCycler 96 Real-Time PCR System (Mannheim Germany) with SYBR Green Supermix (Bio-Rad Laboratories, Hercules, CA), according to the manufacturers instructions

In tumor cells, a switch of glucose metabolism from aerobic glycolysis to oxidation leads to inhibition of proliferation and induction of caspase-mediated apoptosis 82