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Methods Adults with previously untreated, high-risk HER2-positive eBC (T3 or node-positive [N13], including inflammatory disease) were randomized 1:1:1 to: T-DXd-THP: T-DXd 5.4 mg/kg every 3 weeks 4 cycles THP 4 cycles (n=321) ddAC-THP: Doxorubicin + cyclophosphamide every 2 weeks 4 cycles THP 4 cycles (n=320) T-DXd alone: 5.4 mg/kg every 3 weeks 8 cycles (n=286) The primary endpoint was pathologic complete response (pCR

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This remarkable therapeutic window suggests low potential for dose-related toxicity and flexibility in clinical dosing

Trials of selected bioactive compounds, such as coenzyme Q10, curcumin-based formulations, L-carnitine and certain probiotics, suggest beneficial effects on symptoms, whereas others show little or no effect