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Description

Abstract Approved anticancer drugs typically face challenges due to their narrow therapeutic window, primarily because of high systemic toxicity and limited selectivity for tumors

doi: 10.2741/3413 129 Seyed ToutounchiNHogenkampAVarastehSVant LandBGarssenJKraneveldADet al

and Rehman

BU first dose pharmacokinetic parameters were estimated and adjusted from the 3rd to 6th dose, aiming to achieve a steady state concentration between 600 and 900 ng/mL ( ) was administered as a 15 min i.v