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4.3 Multiple sclerosis Multiple sclerosis (MS) occurs as an autoimmune response to autoantigens mediated by autoreactive T cells secondary to environmentally triggered genetically susceptible hosts (80)

Methods in Molecular Biology, vol 2367

Bao et al (60) found downregulation of the ferroptosis regulator GPX4 in both Fpnfl/fl/NEXcre (NEX-Cre mice were mated with Fpn-floxed (Fpnfl/fl) mice to generate conditional Fpnfl/fl/NEXcre mice.) and APPswe/PS1dE9 (Carrying genetically modified mice with AD-related mutations: a chimeric mouse/human APP with the Swedish mutation and human PSEN1 lacking exon 9) mouse models compared with controls