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Overall, characterization of PRO measures across the BSA spectrum showed that the burden of psoriasis was similar in patients with low, medium, and high BSA involvement at the time of initiating biologic therapy, suggesting that treatment decisions are being made to use biologics in appropriate patients with low BSA involvement

Analysis of the mutational landscape across 13 oncogenic genes within a cohort of 57 BCCs revealed a high frequency of genetic alterations

In one study, fatigue was also found to be the most important contributor to levels of physical functioning (81)

Changes in functional connectivity have also been shown using functional MRI, where functional connectivity between two regions is defined as the similarity (commonly Pearson correlation) between the BOLD signal from those regions-