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One way to accomplish this is to inhibit NADPH oxidase (NOX), which is responsible for the formation of O 2 and, subsequently, the formation of ONOO

Numerous studies have shown that DMF has antioxidant and cytoprotective effects in nonmalignant models (28, 30, 31) via its activation of the nuclear factor erythroid 2related (NF-E2 related) factor 2 (NRF2) pathway (28, 3033)