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Furthermore, the synergistic action of disulfiram and Cu2+ enhanced ROS production and activated the p38 mitogen-activated protein kinase (MAPK) signaling pathway

Pelaia G, Vatrella A, Gallelli L, Renda T, Caputi M, Maselli R, Marsico SA

The inherent multi-component nature of TCM formulations enables simultaneous regulation of lactate production, transport, and utilisation pathways, while concurrently targeting enzymatic mechanisms governing lactacidification dynamics and their downstream pathological consequences