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Pathophysiological Mechanisms and Etiology of CLBP Intervertebral disc degeneration is frequently implicated in discogenic pain, as degenerative disc disease leads to loss of disc height, annular fissures, reduced shock absorption, and internal disc disruption that may provoke nociceptive signaling from the annulus fibrosus [6,7]

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In fact, they were originally thinking of adding more spots to further spread the Botox around to hit more nerve endings, but they settled on the current pattern to make it easier and less complex to do

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