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doi: 10.1016/j.ijbiomac.2024.137242 73 BornesTDAdesidaABJomhaNM

In addition, the CGI 08771-01 gene product may reduce activation of these inflammatory cells and be useful as a protein therapeutic to reduce or eliminate the symptoms in patients with Crohn's disease, ulcerative colitis, multiple sclerosis, chronic obstructive pulmonary disease, asthma, emphysema, rheumatoid arthritis, lupus erythematosus, or psoriasis

That said, there are still some risks associated with supplementing vitamin B12 if you arent deficient: A 2015 study found that excess vitamin B12 is associated with acne and rosacea

Tryptophan, an essential amino acid, is metabolized by gut bacteria to produce indole and indole derivatives that serve as aryl hydrocarbon receptor (AhR) ligands, participating in the regulation of intestinal barrier function and immune homeostasis (14)