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By capturing molecular features such as aromaticity, hydrophobicity, charge, and hydrogen bond donor/acceptor properties, pharmacophore fingerprints enable the assessment of similarity between target binding sites, considering energy-minimized conformations of molecules to extract key pharmacophore features [101]

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24] Commentary Circuit Judge Stoll disagreed with the majority of the CAFC, finding that the District Court had incorrectly applied the legal test for obviousness

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