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The efficacy endpoint was the rate of incident HIV-1 infections per 100 person-years in participants randomized to YEZTUGO compared with the rate of incident HIV-1 infections per 100 person-years in participants randomized to TRUVADA

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5 Oxidative stress and epigenetic modifications in DR Long-term hyperglycemia triggers epigenetic modifications, which, without altering the DNA sequence, regulate gene expression through mechanisms like DNA methylation, histone modification, and noncoding RNA expression (105)