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In class I AARSs, the release of activated tRNA (tRNA-AA) is the rate-limiting step whereas in class II AARSs it is the amino acid activation step

T., Xu, S., Wisniewski, D., Evans, J

250 Additionally, Furthermore, pathological antibodies secreted by B cells bind to the HSPA4 receptor on the surface of tumor cell membranes, thereby initiating downstream signaling pathways that activate the NF-B pathway in tumor cells