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Niwa et al., 2007) and the induction of both ER stress and toxicity (Alvarez-Zaldiernas et al., 2016

(2014) 16:e18852

Therefore, lncRNA NORAD has a role in attenuating endothelial cell injury and alleviating AS (226)

The key histological abnormalities of AD include necrosis and apoptosis of VSMCs, fracture of elastic fibers, and degradation of extracellular matrix (ECM) (73).The thrombi formed within the false lumen indicates the presence of continued inflammation under the condition of atherosclerosis and chronic inflammation, and the higher risk of rupture in patients with inflammatory diseases demonstrates the importance of inflammation in AD (74)