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Notably, curcumin activates 5-adenosine monophosphate-activated protein kinase (AMPK) and inhibits mTOR (Zuo et al., 2021), remodels autophagy homeostasis to eliminate UV-induced damaged proteins, and regulates the Bcl-2/caspase-3 balance (Liu et al., 2018) and CD39/CD73-adenosine pathway (Manica et al., 2024), achieving a precise balance between anti-apoptosis and pro-repair

Additionally, C-X-C chemokine ligand 12 (CXCL-12), also known as stromal cell-derived factor-1 (SDF-1), and C-X-C chemokine receptor type 4 (CXCR4) are chemokines responsible for facilitating the entry of bone marrow-derived cells (BMDC) into irradiated tissue [27]

Its ability to activate autophagy, leading to increased angiogenesis, reduced apoptosis, and diminished oxidative stress, is particularly notable Trehalose stimulates the expression of Vascular Endothelial Growth Factor (VEGF) and cadherin 5, alongside an increase in MMP9 expression, thereby augmenting the viability of skin flaps

Gautham Reddy 6 Christophe Corpechot 7 Susheela Carroll 8 Ke Yang 9 Daria Crittenden 8 Charles McWherter 9 , 1 Liver Institute Northwest, 2 California Pacific Medical Center, 3 Weill Cornell Medical College, New York, NY, 4 California Liver Reasearch Institiute, 5 Beth Israel Deaconess Medical Center, Boston, MA, 6 University of Chicago Medical Center, 7 Saint-Antoine Hospital, Paris, France, 8 CymaBay Therapeutics Inc, 9 CymaBay Therapeutics Background: Alkaline phosphatase (ALP) is an important marker in primary biliary cholangitis (PBC) associated with risk for disease progression