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At physiological pH, cytochrome c has a net positive charge (+8), establishing an electrostatic bond with the anionic cardiolipin (Gonzalvez and Gottlieb, 2007)

The following sections detail how this axis interacts with and can be leveraged to enhance chemotherapy, radiotherapy, targeted therapy and immunotherapy

Recognizing early signs and acting swiftly ensures the individual has the best chance of recovery, underscoring the importance of prompt medical attention in cases of suspected overdose