does ghk-cu lower igf-1 igf 1 GHK-Cu Copper Peptide (100MG) Injectable Peptides for Anti-Aging? A

doi: 10.1152/ajplung.00105.2007 24

What they found: 4,192 human genes change expression by 2 in response to GHK-Cu (31.2 % of the human genome) Of these 2,296 genes up-regulated , 1,896 down-regulated Pattern of changes: a rejuvenating signature, genes typically associated with ageing are down-regulated, regenerative genes up-regulated DNA repair , strong up-regulation of genes in BER, HR, NER pathways Mitochondrial biogenesis , increase in the number of mitochondria in cells Anti-apoptotic signal , protection against cell death Down-regulation of cancer signals , some oncogenes decreased Why it matters: This is the strongest evidence for the pleiotropic nature of GHK-Cu

After this treatment, the level of the Nuclear factor kappa B (NF-B) was reduced and thereby its activity was also reduced

Patients should be counseled about pancreatitis symptoms (severe persistent abdominal pain radiating to the back, nausea, vomiting) and seek immediate medical attention if they occur