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Many OXPHOS inhibitors or SHMT2 inhibitors exhibit narrow therapeutic windows and significant side effects [187]

Then, the rats were anesthetized with ketamine/xylazine (100 mg/kg and 10 mg/kg) cocktail injected by peritoneum and followed by non-invasive ventilation (Harvard 683 rodent ventilator) with pure oxygen, and fixed on the surgical table covered by a sterile surgical drape