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Furthermore, we recognize our mouse model is different from the previously studied AKITA mouse model ( M

10.1177/1535370219900637 68 SarafS

What they rarely expect is that ten years later, they will still be managing it, adjusting it, and learning from it

The gut microbiota produces its own antigens through protein post-translational modifications, activates Toll-like receptor 4 induced by lipopolysaccharide (LPS), induces T helper cell translocation from type 1 (Th1) to type 2 (Th2), reduces the integrity of intercellular connections, and promotes AITD development through intestinal leakage (Lerner et al., 2017)