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circHIPK3, a circular RNA, promotes intestinal epithelial cell repair and regeneration by sequestering miR-29b and regulating factors such as Rac1, Cdc42, and Cyclin B1 [398]

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In this study, drug candidates were selected for further analysis if their connectivity scores were lower than 0.8

Herein, the genetic susceptibility mechanisms of IBD, the specific impacts of environmental and lifestyle factors, and their interactive patterns are systematically reviewed, with particular emphasis on the mechanistic pathways of modifiable factors, with the aim of providing practical guidance for the development of personalized prevention strategies and therapeutic interventions