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Afterward, maintenance injections may be recommended monthly to help sustain optimal B-12 levels

In addition, melatonin inhibits the expression of cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) 75 and limits the production of excessive amounts of prostanoids and leukotrienes and nitric oxide (NO), as well as other mediators of the inflammatory process, such as chemokines and adhesion molecules 73,76 (Fig

[17] Miscellaneous agents Apart from these, large doses of vitamin C, hyaluronic acid, epidermal growth factor and combinations of multiple natural extracts (natural collagen extracts, bearberry extract, Glycyrrhiza glabra extract, Lycopene, Kelp, olive leaf extract, hawthorn, jujube, sea buckthorn, starch, coix seed, pearl extracts, etc.,) are also promoted for skin whitening in the form of food or dietary supplements with no scientific evidence

& Xu, L