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In vivo , chronic treatment with opioids promotes decrease (down-regulation), no change or increase (up-regulation) of OR (Bernstein and Welch, 2001

Ferranti R, da Silva MM, Kowaltowski AJ

Saisho Y

demonstrated that Tom20 or Bax knockout effectively blocks ROS-induced pyroptosis, while antioxidant treatment significantly reduces Tom20 oxidation, Bax mitochondrial recruitment, and GSDME cleavage, further confirming that ROS serves as the central regulator of this signaling pathway (47)