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These results suggest that Thr deprivation triggers the synthesis of a protein(s) that executes non-apoptotic, non-necropotic, or non-ferroptotic death in a Met- and mTOR-dependent manner

Figure 3 Collectively, our findings suggest a role for NLRP3-mediated ASC-speck formation and caspase-1 activation in pathologic inflammation associated with moderate and severe forms of COVID-19 supporting potential use of NLRP3 inhibition to mitigate the exacerbated inflammasome-related responses during COVID-19

Changes in expression levels are known to change rapidly following perturbation, for example, heat shock or activation with Lipopolysaccharide (LPS) or other agents

The high prevalence of HCV-RNA viremia at 15.3% of the study cohort emphasizes the need for targeted HCV care for this underserved population