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In: Bentley G, editor

Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks

The protocols in use come from extrapolation of animal data, pharmacokinetic studies, and clinical experience from practitioners who have incorporated the compound into their practice