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doi: 10.1021/acs.biomac.7b00846 121 HanJMKimHLJungHJ

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307,308 Various clinical trials have demonstrated the efficacy of DBS in lessening motor symptoms associated with Parkinsons disease

In terms of translational potential, -[1- 13 C]gluconolactone fulfills the requirements for a successful hyperpolarized 13 C agent such as T 1 , chemical shift separation, safety and BBB permeability (a necessity for studies in the brain) (23)

evening maximizes effectiveness Peptides can amplify retinol's overnight repair Separate AM/PM (alternative approach): Morning: Peptide serum + Vitamin C + SPF Evening: Retinol + Moisturizer Why: Spreads actives across day