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It serves as a protective mechanism to regulate the passage of substances across the BBB and prevents physiologically irrelevant molecules in the peripheral circulation from entering the brain

Urakaze, M., Kobashi, C., Satou, Y., Shigeta, K., Toshima, M., Takagi, M., Takahashi, J., & Nishida, H

Another study showed that elevated insulin levels promote the proliferation of thecal cells and increase the secretion of androgens, including luteinizing hormone (LH), while also upregulating the expression of cytochrome P450 and insulin growth factor-1 (IGF-1) receptors (107)