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doi: 10.1016/j.yexcr.2021.112800 64 ZhuZDuanPSongHZhouRChenT

PepGen developed a POC drug, PGN-EDO51, using its enhanced delivery oligonucleotide platform, which skips exon 51 in the DMD gene

[DOI] [PubMed] [Google Scholar] Sies H, Berndt C, Jones DP

Together, these data indicate that FAO reprogramming in lung-associated macrophages occurs via a DUSP5-mediated mechanism in response to BCG infection and offers both DUSP5 modulation, and FAO inhibition, as potential therapeutic avenues to modify the severity of sequelae associated with Mtb infection