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Low ROS levels activate cell survival signaling pathways, such as the unfolded protein response and Nrf2 pathways, whereas high ROS levels activate cell death signaling pathways, such as apoptosis and necroptosis pathways 43

After reconstitution, store under refrigeration and handle according to standard laboratory procedures

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Because of the likelihood that HIV infection results in an increased oxidative load, it has been suggested that increased conversion of GSH to its oxidized form glutathione disulfide (GSSG), which can be exported from the cell, leads to increased consumption of GSH (24)