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Some research shows theres added potential for tirzepatide when its used in conjunction with hormone replacement therapy (HRT)

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Mathiesen DS, Bagger JI, Bergmann NC, Lund A, Christensen MB, Vilsboll T, et al

It may stimulate growth hormone release, modulate cortisol levels through HPA axis effects, and influence luteinizing hormone

Furthermore, BPC 157 eliminated systemic corticosteroid treatment functionally, macroscopically, and histologically at all investigated intervals [46]