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IL-17 blockers (eg secukinumab, Ixekizumab, brodalumab and bimukizumab) and IL-23 blockers (guselkumab, risankizumab & tildrakizumab) are safer and easier to prescribe than anti-TNF biologics and require less monitoring and pre-treatment investigation

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For instance, alginate CpG hydrogels or chitosan-based depots have demonstrated sustained DC activation and prolonged immune stimulation in preclinical melanoma models, yet such materials also introduce workflow complexity and manufacturing burden

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