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10f-THF: 10-formyltetrahydrofolate 5mTHF: 5-methyltetrahydrofolate AICAR: P-ribosyl-5-amino-4-imidazole carboxamide CH = THF: 5-10-methenyltetrahydrofolate CH2-THF: 5-10-methylenetetrahydrofolate Cys: cysteine Cysta cystathionine DHF: dihydrofolate DMG: dimethylglycine dTMP: deoxythymidine monophosphate dUMP: deoxyuridine monophophate GAR: glycinamide ribonucleotide Glut: glutamate Glut: Cys glutamyl-cysteine Gly: glycine

In particular: It reduces Oxidative Stress , which accelerates skin aging and worsens Acne

Ang II can promote the differentiation of aortic adventitial fibroblasts into myofibroblasts by inducing the phosphorylation of ERK1/2 and aggravate the formation of AD (120)

8 Conclusion Global aging has resulted in an enormous increase in the population of older people and an enormous challenge to global public health