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At the cellular level, CKD is remarkable by oxidative stress, abnormal autophagy, and mitochondrial dysfunction accompanied by significant alterations in cell signaling pathways such as HIF, TGF-, and p53 activation [21]

(2012) further optimized the hydrogen intervention strategy by comparing the effects of hydrogen water with lactulose (a synthetic disaccharide that generates hydrogen gas through gut microbiota metabolism) in a PD model