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AD is characterized by the accumulation and aggregation of misfolded proteins in brain, the sustained activation of the UPR mediated by the misfold proteins initiates or mediates neurodegeneration (Hoozemans et al., 2005)

Besides, Enterobacter aerogenes ZDY01 and Lactobacillus casei have also been shown to reduce circulating TMAO levels in murine model (Qiu et al., 2017