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Although the body produces it naturally, factors like stress, poor diet, ageing, pollution and illness can reduce its levels, making supplementation helpful for many individuals

LDL circulating in the plasma appears to be protected from oxidation, both by dietary antioxidants such as vitamin E and C (259) and by protective enzymes including glutathione peroxidases (260,261), peroxiredoxins, PAF-acetylhydrolase (also known as lipoprotein-PLA2) (262,263), and paraoxonases (PON) (264,265)

Effective surface passivation minimises non-radiative energy loss and photobleaching, which offers a rationale for the continuous fluorescence behaviour frequently reported in imaging studies

The compound was first identified in 1973 by Dr