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Although, the authors suggested that the HO-1 induction was uniquely due to its antioxidant properties, it is clear now that the elevation of HO-1 levels also represents an attempt to downregulate inflammation [50]

This inherent stability allows it to remain biologically active for extended periods, a characteristic that makes it suitable for oral administration in research settings, particularly for studies focused on gastrointestinal health

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Early studies found that expression of members of the interleukin (IL) family of cytokines, such as IL-6 and IL-8, was strongly correlated with cancer relapse and a poor response to chemotherapy (46, 47)