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It experimentally induced inflammatory reactions in the rat with the interference of eicosanoid formation in the arachidonic acid cascade (124) and could modulate the immune system as an anti-inflammatory factor ( Habashi and co-authors have also reported that bromelain potentially exerted anti-inflammatory effects by reducing nitric oxide synthesis in vitro without cytotoxicity (137)

There was also the perception among some service providers that if victims were unwilling to cooperate with law enforcement and/or if prosecutors were unable to make a legal case for human trafficking, these law enforcement agencies would not consider these persons as real victims, which could negatively affect the ability of providers to secure necessary services for them

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The granulosa cells are a significant site of ROS, as they help in steroidogenesis, and to combat this, melatonin plays a key role by lowering ROS and MDA levels (191)